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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations

Fig. 3

Grandmaternal (G0) vitamin D deficiency is linked to G2 offspring developmental outcomes. a G2 male and female PND4, PND9 (female N = 40, 35, 23, 21 and male N = 49, 24, 31, 24, respectively) and male 8 weeks (N = 20, 10, 13, 11) body weight. b G2 male 8 weeks body composition (N = 23, 10, 13, 11). c Combined testes weight (upper panel) and testes weight corrected for body weight (bottom panel) (N = 21, 10, 13, 11). d Total sperm count (N = 23, 10, 13, 11). Each dot represents an individual sample. Error bars represent standard error of the mean. Asterisks (*) or (***) indicate p value <0.05 or 0.005 determined by t test within each cross; panel above each graph lists all statistically significant (p value <0.05) comparisons determined by regression analysis for overall diet dependent effects (diet), diet-independent grandparent of origin effects (GPO), and diet-dependent grandparent of origin effects (diet × GPO). n.s. not significant

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