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Table 5 The performance of individual and combined applications of the two classes of sputum biomarkers for lung cancer detection

From: Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection

Biomarkers AUC (95 % CI) Sensitivity (95 % CI) Specificity (95 % CI) P value
The panel of the 3 miRNA biomarkers 0.89 (0.82 to 0.93) 81.50 (68.57 to 90.75) 85.91 (72.41 to 93.25) <0.001
The panel of the 3 DNA methylation biomarkers 0.79 (0.72 to 0.87) 82.9 (71.97 to 90.82) 76.43 (64.91 to 85.60) <0.001
Combined analysis of the two classes of sputum biomarkers 0.93 (0.89 to 0.96) 87.34 (77.95 to 93.76) 90.35 (80.12 to 96.37) <0.001
  1. Abbreviations: NSCLC non-small cell lung cancer, AUC the area under receiver operating characteristic curve, CI confidence interval