Table 5 The performance of individual and combined applications of the two classes of sputum biomarkers for lung cancer detection
From: Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection
Biomarkers | AUC (95Â % CI) | Sensitivity (95Â % CI) | Specificity (95Â % CI) | P value |
|---|---|---|---|---|
The panel of the 3 miRNA biomarkers | 0.89 (0.82 to 0.93) | 81.50 (68.57 to 90.75) | 85.91 (72.41 to 93.25) | <0.001 |
The panel of the 3 DNA methylation biomarkers | 0.79 (0.72 to 0.87) | 82.9 (71.97 to 90.82) | 76.43 (64.91 to 85.60) | <0.001 |
Combined analysis of the two classes of sputum biomarkers | 0.93 (0.89 to 0.96) | 87.34 (77.95 to 93.76) | 90.35 (80.12 to 96.37) | <0.001 |