Table 3 DNA hypermethylation of 3 genes in sputum of a training set of stage I NSCLC patients and smokers with benign pulmonary nodules

RASSF1A

0.68 (0.56 to 0.79)

45.3 (32.56 to 56.23)

86.2 (75.38 to 90.56)

<0.001

3OST2

0.69 (0.60 to 0.78)

49.3 (36.58 to 59.59)

84.5 (72.15 to 87.29)

<0.001

PRDM14

0.69 (0.58 to 0.79)

59.3 (47.40 to 68.73)

77.3 (65.5 to 85.16)

<0.001

Combined use of the 3 genes

0.79 (0.72 to 0.88)

82.9 (71.97 to 90.82)

76.4 (64.91 to 85.60)

<0.001