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Table 3 DNA hypermethylation of 3 genes in sputum of a training set of stage I NSCLC patients and smokers with benign pulmonary nodules

From: Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection

Genes AUC (95 % CI) Sensitivity (95 % CI) Specificity (95 % CI) P value
RASSF1A 0.68 (0.56 to 0.79) 45.3 (32.56 to 56.23) 86.2 (75.38 to 90.56) <0.001
3OST2 0.69 (0.60 to 0.78) 49.3 (36.58 to 59.59) 84.5 (72.15 to 87.29) <0.001
PRDM14 0.69 (0.58 to 0.79) 59.3 (47.40 to 68.73) 77.3 (65.5 to 85.16) <0.001
Combined use of the 3 genes 0.79 (0.72 to 0.88) 82.9 (71.97 to 90.82) 76.4 (64.91 to 85.60) <0.001
  1. Abbreviations: NSCLC non-small cell lung cancer, AUC the area under receiver operating characteristic curve, CI confidence interval