Fig. 1
From: Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection
Combined analysis of miRNA and DNA methylation biomarkers in sputum has a synergistic effect for lung cancer detection. a ROC curve of a panel of 3 miRNA biomarkers (miR-21, miR-31, and miR-210) shows an AUC of 0.89 for differentiating NSCLC patients from smokers with benign pulmonary nodules in terms of sensitivity and specificity. b A panel of 3 DNA methylation biomarkers (RASSF1A, 3OST2, and PRDM14) creates an AUC of 0.79 for distinguishing NSCLC patients from the cancer-free smokers. c The integration of 2 miRNAs (miR-31 and miR-210) and 2 TSGs (RASSF1A and 3OST2) yields 0.93 AUC, which is statistically higher than that of the panel of 3 miRNA biomarkers and the panel of 3 methylation biomarkers (P < 0.05)