Fig. 2

Association of DMRs to genes and the importance of associated genes (DMGs) in CLL over normal sorted B cell. a, b Venn diagram shows the overlap of differentially methylated genes (DMGs, hypermethylated and hypomethylated) between IGHV-mutated and IGHV-unmutated groups. The pie chart represents the percentage of different classes of genes such as protein coding, lncRNA, pseudogenes, antisense and other noncoding RNAs. c The heatmap shows enrichment of DMGs (top, subgroup specific and bottom, common DMGs) in different cancer types from Network of Cancer Genes (NCG 4.0). The cancer types are assigned and ranked using GeneSCF. The presented enrichment was filtered using a p value <0.01 with at least 5 % of total cancer genes covered by DMGs. d The heatmap shows the KEGG pathways obtained using DMGs from IGHV-mutated and IGHV-unmutated prognostic groups. The pathways were assigned and ranked using GeneSCF. The presented pathways are filtered using a p value <0.01 with at least 5 % of total pathway genes covered by DMGs (see the “Methods” section). The left side of the heatmap represents the subgroup specific (IGHV-mutated and IGHV-unmutated) hyper- and hypomethylated associated pathways; and the right side of the heatmap for common DMGs between IGHV-mutated and IGHV-unmutated groups (see the “Methods” section)