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Table 5 Differentially methylated loci: smokers vs. nonsmokers separated by tissue type

From: Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use

Tissue

Total No. DML

Promoter DML (%)

Intragenic DML (%)

Intergenic DML (%)

CpG island DML (%)

CpG shore DML (%)

Cancer-associated DML (%)

BE

86

25 (29 %)

43 (50 %)

18 (21 %)

23 (27 %)

28 (32 %)

21 (24 %)

HGD/EAC

802

152 (19 %)

417 (52 %)

233 (29 %)

279 (35 %)

395 (49 %)

79 (10 %)

  1. DML defined by p value <0.001 and Δβ value (smoker vs. nonsmoker) > 0.10 while controlling for age