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Table 5 Differentially methylated loci: smokers vs. nonsmokers separated by tissue type

From: Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use

Tissue Total No. DML Promoter DML (%) Intragenic DML (%) Intergenic DML (%) CpG island DML (%) CpG shore DML (%) Cancer-associated DML (%)
BE 86 25 (29 %) 43 (50 %) 18 (21 %) 23 (27 %) 28 (32 %) 21 (24 %)
HGD/EAC 802 152 (19 %) 417 (52 %) 233 (29 %) 279 (35 %) 395 (49 %) 79 (10 %)
  1. DML defined by p value <0.001 and Δβ value (smoker vs. nonsmoker) > 0.10 while controlling for age