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Table 3 Differentially methylated loci (p < 5 × 10−6): females vs. males (BE, HGD/EAC combined)

From: Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use

Probe ID Gene Average β females Average β males (overall change) p value Probe location Relative expression BE vs. normal^ Relative expression EAC vs. normal^ Relation to island
cg17272795 ZNF37A 0.34 0.10 (↓) 1.76E-09 TSS1500 1.06* −1.05* Shore
cg07753967 FRG1B 0.44 0.10 (↓) 2.13E-09 TSS1500 NS NS Island
cg25791279 PISD 0.26 0.15 (↓) 8.77E-09 TSS200 NS 2.17–3.20* Shore
cg25489030 FRG1B 0.46 0.30 (↓) 3.63E-08 Body NS NS Island
cg02531214 ZNF37A 0.34 0.13 (↓) 1.76E-07 TSS1500 1.06* −1.05* Shore
cg20811988 FRG1B 0.33 0.11 (↓) 7.17E-07 Body NS NS Island
cg03395511 DUSP22 0.11 0.42 (↑) 8.15E-07 TSS200 NS NS Shore
cg14815891 FRG1B 0.33 0.08 (↓) 1.03E-06 Body NS NS Island
cg01516881 DUSP22 0.07 0.23 (↑) 1.23E-06 Body NS NS Island
cg21508714 RBM20 0.31 0.12 (↓) 1.42E-06 Body NS NS Island
cg11386792 RBM20 0.44 0.13 (↓) 1.74E-06 Body NS NS Island
cg16004008 NRGN 0.35 0.20 (↓) 1.91E-06 TSS1500 1.45–1.46* 1.57–3.23* Shore
cg03066577 C3orf55 0.26 0.11 (↓) 2.17E-06 5′UTR; 1st exon; body NS 4.95* Island
cg21548813 DUSP22 0.08 0.36 (↑) 2.25E-06 TSS1500 NS NS Shore
cg14819088 SLC34A1 0.67 0.78 (↑) 2.52E-06 TSS200 NS NS Open sea
cg15383120 DUSP22 0.08 0.38 (↑) 2.52E-06 TSS200 NS NS Shore
cg18110333 DUSP22 0.09 0.39 (↑) 3.92E-06 1st exon; 5′UTR NS NS Island
cg16602806 MTRR 0.19 0.09 (↓) 4.59E-06 Body; TSS1500; 5′UTR 1.65* 1.77* Shore
cg25959506 RASD2 0.27 0.11 (↓) 4.91E-06 TSS1500 NS NS Island
  1. 5′UTR = 5′ untranslated region; TSS200/TSS1500 = 200 or 1500 bp’s upstream from transcription start site; Shore = DNA sequence up to 2 kb from CpG island; Open sea = DNA sequence >4 kb from CpG island; NS = not significant; ^ = relative gene expression data obtained from www.oncomine.org; *p ≤ 0.05; (↑)/(↓) = increase/decrease in methylation in male vs. females