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Table 2 Differentially methylated loci: high BMI vs. low BMI cases separated by tissue type

From: Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use

Tissue Total number of DML Promoter DML (%) Intragenic DML (%) Intergenic DML (%) CpG island DML (%) CpG shore DML (%) Cancer-associated DML (%)
BE 288 85 (29 %) 129 (45 %) 74 (26 %) 113 (39 %) 108 (37 %) 60 (21 %)
LGD 372 120 (32 %) 166 (45 %) 86 (23 %) 226 (61 %) 166 (45 %) 252 (68 %)
HGD/EAC 270 73 (27 %) 156 (58 %) 41 (15 %) 53 (20 %) 111 (41 %) 40 (15 %)
  1. DML defined by p value <0.001 and Δβ value (high BMI vs. low BMI) > 0.10 while controlling for age