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Table 2 Differentially methylated loci: high BMI vs. low BMI cases separated by tissue type

From: Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use

Tissue

Total number of DML

Promoter DML (%)

Intragenic DML (%)

Intergenic DML (%)

CpG island DML (%)

CpG shore DML (%)

Cancer-associated DML (%)

BE

288

85 (29 %)

129 (45 %)

74 (26 %)

113 (39 %)

108 (37 %)

60 (21 %)

LGD

372

120 (32 %)

166 (45 %)

86 (23 %)

226 (61 %)

166 (45 %)

252 (68 %)

HGD/EAC

270

73 (27 %)

156 (58 %)

41 (15 %)

53 (20 %)

111 (41 %)

40 (15 %)

  1. DML defined by p value <0.001 and Δβ value (high BMI vs. low BMI) > 0.10 while controlling for age