Scheme 8From: Epigenetic polypharmacology: from combination therapy to multitargeted drugsMechanism of N-methyl lysine demethylation by the JHDM enzymes. The numbering is that of JMJD2A/KDM4a, which catalyzes demethylation of H3K9me2, H3K9me3, and H3K36me3Back to article page