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Fig. 3 | Clinical Epigenetics

Fig. 3

From: The emerging role of lysine methyltransferase SETD8 in human diseases

Fig. 3

SETD8 protein–protein interaction network, obtained with Cytoscape v. 3.4.0 [105] using STRING database [106]. Only proteins directly interacting with SETD8 are displayed as colored glass-like marbles: histone cluster 1, H4a (HIST1H4a, red), lymphoid enhancer-binding factor 1 (LEF1, aquamarine), proliferating cell nuclear antigen (PCNA, violet red), denticleless protein homolog (DTL, also known as CDT2, persian blue), tumor protein p53 (p53, tan), protein numb homolog (NUMB, green). SETD8 is depicted in orchid. Direct interactions of SETD8 with protein targets leading to post-translational modifications are depicted as orange arrows, protein–protein interactions leading to SETD8 degradation as lime arrows, binding interactions as cornflower lines. Other interactions are shown as gray lines. Interactions of SETD8 with proteins PLOD1–3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase, shades of gray) were also retrieved from the interrogation of the STRING database, yet we found no evidence in the literature. Therefore they are shown as dotted gray lines

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