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Table 2 Top 30 CpGs differentially methylated in blood DNA in relation to current smoking compared to never smoking (FDR < 0.05, ordered by chromosomal location)

From: DNA methylation and smoking in Korean adults: epigenome-wide association study

Chra Gene Distance to geneb Probe Positionc Coefd SEe P f
2 CCDC104   cg21597209 55746709 −0.009 0.002 6.2E−07
DGUOK   cg19394739 74154363 −0.012 0.002 3.5E−07
CLASP1   cg22346073 122402890 −0.056 0.010 5.1E−08
SATB2   cg21136715 200322252 −0.035 0.006 2.1E−07
ALPPL2 12,850 cg05951221g 233284402 −0.088 0.014 8.4E−09
3 GPR15   cg19859270g 98251294 −0.027 0.005 1.0E−07
5 AHRR   cg05575921g 373378 −0.203 0.025 6.5E−13
  cg25648203g 395444 −0.079 0.015 6.2E−07
LINC01019 −239,389 cg11405538 3177877 0.124 0.022 1.3E−07
SOX30   cg06995810 157079468 0.048 0.009 1.0E−06
7 TSPAN13   cg05848863 16794078 −0.024 0.004 3.6E−07
PLEKHA8   cg09762120 30108301 0.040 0.007 2.8E−08
ADCYAP1R1   cg20165074 31091813 −0.008 0.002 6.7E−07
10 FAM53B   cg20723792 126360669 −0.097 0.014 4.8E−10
11 IRF7   cg27271532 612762 −0.035 0.006 3.8E−07
E2F8   cg15604507 19263433 −0.021 0.004 5.7E−07
CCND1   cg09520904 69462943 −0.036 0.007 7.5E−07
DIXDC1   cg11471799 111807548 −0.023 0.004 6.2E−07
12 CDK2AP1   cg13421247 123756945 −0.058 0.011 9.8E−07
14 CFL2 −44,147 cg23429457 35135441 −0.040 0.007 2.0E−07
EXOC3L4 −20,369 cg04884342 103546112 0.020 0.004 5.6E−07
15 CALML4   cg00388154 68498857 −0.058 0.011 2.9E−07
CORO2B   cg18765659 69018349 −0.053 0.010 7.4E−07
TLE3   cg06730438h 70355664 −0.016 0.003 4.9E−07
16 ALDOA   cg24780263 30064201 −0.011 0.002 1.8E−08
KIAA0182   cg26723054 85650522 −0.038 0.007 7.2E−07
19 F2RL3   cg03636183g 17000585 −0.128 0.021 2.0E−08
DDA1   cg10664184 17420304 −0.028 0.004 9.2E−11
CD33   cg06861672 51727798 −0.036 0.007 3.3E−07
21 MIR155HG   cg03872783 26934885 −0.008 0.001 9.7E−07
  1. aChromosome
  2. bDistance to transcription start site of the mapped gene (basepair)
  3. cPhysical position (basepair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  4. dRegression coefficient from statistical model
  5. eStandard error of regression coefficient
  6. fStatistical significance from statistical model
  7. gProbe identified in previous epigenome-wide association studies (EWASs) of smoking
  8. hProbe mapped to genes identified in previous EWASs of smoking
  9. DMPs ordered by p values can be found in Additional file 10