From: DNA methylation and smoking in Korean adults: epigenome-wide association study
Characteristics (mean ± standard deviation or n (%)) | Genome-wide methylation analysis in blood DNA (the Korean COPD cohort) | Transcriptome analysis in lung tissue (Asan Biobank) | ||
---|---|---|---|---|
Never smoker (N = 39) | Former smoker (N = 30) | Current smoker (N = 31) | ||
Male | 6 (15.4) | 30 (100) | 30 (96.8) | 188 (100) |
Female | 33 (84.6) | 0 (0) | 1 (3.2) | 0 (0) |
Age, years | 72.9 ± 6.1 | 74.1 ± 7.4 | 71.5 ± 5.3 | 64.2 ± 8.7 |
Body mass index, kg/m2 | 23.2 ± 3.0 | 23.5 ± 2.7 | 22 ± 2.8 | NA |
Pack-year | NAc | 28.9 ± 19.6 | 35.7 ± 19.1 | 42.0 ± 20.6 |
Duration of smoking cessation, years | NA | 17.6 ± 7.5 | NA | NA |
Urine cotinine, nmol/L | 88.4 ± 3.2d | 167.6e | 29421 ± 21947 | NA |
Undetectablea | 36 (92.3) | 29 (96.7) | 0 (0) | NA |
COPDb | 19 (48.7) | 20 (66.7) | 21 (67.7) | 98 (51.9) |