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Table 2 Results

From: Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review

 

Candidate gene studies

Array studies

Study

Oberlander et al. (2008) [22]

Soubry et al. (2011) [26]

Devlin et al. (2010) [25]

Schroeder et al.c,d,e

(2012) [27] (27 K)

Non et al.b,e

(2014) [28] (450 K)

Gurnot et al.c,d,e

(2015) [29] (27 K)

Gene

CPG sites

β-coefficient (p value)

β-coefficient (p value)

Mean methylation % ± SE

Average methylation change % (p value)

β-coefficient (95 % CI)

β-coefficient (SRI-exposed/non-exposed)*

TNFRSF21

cg22464186

-

-

-

−1.9 (2.8 x 10−6)

NS

NS

CHRNA2

cg02953306

 

-

-

3 (3.1 x 10−6)

NS

NS

CYP2E1

cg13315147

-

-

-

NS

NS

0.30/0.06

EVA1

cg18399703

-

-

-

NS

NS

0.06/0.04

SLMAP

cg11743795

-

-

-

NS

NS

0.03/0.02

NR3C1

CpG1 (D (HAM-D))

0.317 (0.0011)

-

-

-

NS

 
 

CpG2 (D (HAM-D))

(2nd/3rd trimester)

0.253 (0.066)/

0.371 (0.003)

-

-

-

-

-

 

CpG3 (D (HAM-D))

0.284 (0.023)

-

-

-

-

-

 

cg00629244 (D)

-

-

-

 

−0.006 (−0.01,−0.003)a

 

BDNF

Unspecific

-

–

NS

NS

NS

NS

IGF2

IGF2 DMR (D/M)

-

0.72(0.5)/−0.47(0.71)

–

NS

NS

NS

IGF2

H19 DMR (D/M)

Race interaction (M)

-

0.25 (0.84)/0.54(0.7) 9.18 (0.002)

-

NS

NS

NS

SLC6A4

CpG 6 (D)

-

-

4.61 ± 2.1

-

-

-

 

CpG 9 (D)

-

-

8.31 ± 3.2

-

-

-

 

cg10901968 (M)

-

-

-

NS

−0.007 (−0.01,-0.003)*

NS

FKBP5

cg18726036 (D)

-

-

-

NS

0.009 (0.004, 0.01)a

NS

 

cg07061368 (M)

-

-

-

NS

−0.03 (−0.05,-0.01)a

NS

CRHR1

cg11731737 (D)

-

-

-

NS

−0.005(−0.01,-0.002)a

NS

 

Unspecific

-

-

-

NS

NS

NS

NFKB1

Unspecific

-

-

-

NS

NS

NS

NFKB2

cg23606922 (D/M)

-

-

-

NS

−0.007(−0.01,−0.003)*/−0.01(−0.02,-0.01)*

NS

DNMT1

Unspecific

-

-

-

NS

NS

NS

DNMT3a

cg15843262 (M)

-

-

-

NS

0.008 (0.004,0.01)*

NS

 

Other CpG sites d

-

-

-

NS (6 sites of the 42)d

42 sites ass. with maternal depressiond

NS (6 sites of the 42)d

  1. The β-coefficient represents difference in percent methylation in the exposed vs. the unexposed
  2. D Associated with maternal depression, M associated with maternal medication, HAM-D Hamilton depression scale
  3. NS tested and not found statistically significant (FDR-adj. p value >0.05). Reported by the specific studies
  4. -not tested
  5. *Significantly associated sites (p value <0.001).aMarginally significant sites.
  6. bThe Illumina HumanMethylation 450 BeadChip.cThe Ilumina HumanMethylation 27 BeadChip.
  7. dThe other significant (FDR-adj. p value <0.1) CpG sites consist of 42 sites found with the 450K from a range of other genes not investigated by any of the other studies and only associated to maternal depression but not the maternal use of antidepressant medication. Only 6 out of these 42 CpG sites were also investigated by the other 2 array studies and no association reported
  8. eThe 27K and 450K have tested several other CpG sites within the listed genes, but not found any statistically significant methylation differences
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Clinical Epigenetics

ISSN: 1868-7083

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