Study | Setting/location | N | Study period | Exposure measures | Study material | Outcome measures |
---|---|---|---|---|---|---|
Oberlander, T. et al. (2008) [22]c | Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada | 98 mother-child dyads: - 33 SRI-exposed, depressed - 49 non-medicated (13 depressed, 36 not depressed) - 16 not analyzed | Missing | Depression: - HAM-D - HAM-A - EPDS | - Whole blood from the mother. - Cord blood from the child. | Pyrosequencing: Methylation status of NR3C1 CpG rich region |
Soubry, A. et al. (2011) [26] | Newborn Epigenetics Study (NEST), Duke University, Durham NC, USA | 436 mother-child dyads: - 44 AD-treated, depressed (SSRI, SNRI, TCAs, SARi, bupropion) - 66 non-medicated depressed - 326 controls | April 2005-June 2008 | Depression Antidepressant medication | - Cord blood from the child. | Pyrosequencing: H19 and IGF2 DMR’s of the imprinted Insulin-like Growth Factor 2(IGF2) gene. - 331 IGF2 DMR’s - 345 H19 DMR’s (some analyses contained both iDMRs) |
Devlin, A. et al. (2010) [25]c | Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada | 98 mother-child dyads: - 33 SRI-exposed, depressed - 49 non-medicated (13 depressed, 36 not depressed) - 16 not analyzed | Missing | Depression - HAM-D - EPDS | - Whole blood from the mother. - Cord blood from the child. | Pyrosequencing: methylation levels of SLC6A4 and BDNF in pregnant women and their infants. |
Schroeder, J. et al. (2012) [27] | SCOR or TRC0Sa at the WMPHb, Atlanta, Georgia, USA | 201 mother-child dyads: - 83 currently depressed - 146 with lifetime depression - 151 depressed treated with AD (132 SSRI) | Missing | Lifetime psychiatric illness. (DSM-IV) - SCID - HRSD17 - BDI Antidepressant medication in 2 groups: 1. SSRI, SNRI, TCA 2. Bupropion | - Cord blood from the child. | Methylation array: Illumina Human Methylation27 BeadChip |
Non, A. et al. (2014) [28] | Harvard Epigenetic Birth Cohort, Brigham and Women’s hospital, Boston, MA, USA | 58 mother-child dyads: - 13 non-medicated depressed. - 22 SSRI treated, depressed - 23 healthy controls | June 2007-June 2009 | Depression (no score, reported in the chart) SSRI (4 types) | - Cord blood from the child. | Methylation array and candidate gene analysis: Illumina Human Methylation450 BeadChip: Site-by-site Regional clusters Pyrosequencing Gene ontology |
Gurnot, C. et al. (2015) [29] | Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada | 44 women (91 in the cohort): Array analysis: - 12 SRI-exposed depressed - 11 controls (depressed/non-depressed). Pyrosequencing: - 17 SRI-exposed, depressed. - 25 controls (depressed/ non-depressed). | Missing | Maternal mood: - HAM-D Drug levels: - Measured in the maternal blood. | - Cord blood from the child. | Methylation array: Illumina Infinium HumanMethylation27 array. Pyrosequencing: Verification of the methylation status of the CYP2E1 gene (found in array). |