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Table 1 Study overview

From: Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review

Study Setting/location N Study period Exposure measures Study material Outcome measures
Oberlander, T. et al. (2008) [22]c Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada 98 mother-child dyads: - 33 SRI-exposed, depressed - 49 non-medicated (13 depressed, 36 not depressed) - 16 not analyzed Missing Depression: - HAM-D - HAM-A - EPDS - Whole blood from the mother. - Cord blood from the child. Pyrosequencing: Methylation status of NR3C1 CpG rich region
Soubry, A. et al. (2011) [26] Newborn Epigenetics Study (NEST), Duke University, Durham NC, USA 436 mother-child dyads: - 44 AD-treated, depressed (SSRI, SNRI, TCAs, SARi, bupropion) - 66 non-medicated depressed - 326 controls April 2005-June 2008 Depression Antidepressant medication - Cord blood from the child. Pyrosequencing: H19 and IGF2 DMR’s of the imprinted Insulin-like Growth Factor 2(IGF2) gene. - 331 IGF2 DMR’s - 345 H19 DMR’s (some analyses contained both iDMRs)
Devlin, A. et al. (2010) [25]c Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada 98 mother-child dyads: - 33 SRI-exposed, depressed - 49 non-medicated (13 depressed, 36 not depressed) - 16 not analyzed Missing Depression - HAM-D - EPDS - Whole blood from the mother. - Cord blood from the child. Pyrosequencing: methylation levels of SLC6A4 and BDNF in pregnant women and their infants.
Schroeder, J. et al. (2012) [27] SCOR or TRC0Sa at the WMPHb, Atlanta, Georgia, USA 201 mother-child dyads: - 83 currently depressed - 146 with lifetime depression - 151 depressed treated with AD (132 SSRI) Missing Lifetime psychiatric illness. (DSM-IV) - SCID - HRSD17 - BDI Antidepressant medication in 2 groups: 1. SSRI, SNRI, TCA 2. Bupropion - Cord blood from the child. Methylation array: Illumina Human Methylation27 BeadChip
Non, A. et al. (2014) [28] Harvard Epigenetic Birth Cohort, Brigham and Women’s hospital, Boston, MA, USA 58 mother-child dyads: - 13 non-medicated depressed. - 22 SSRI treated, depressed - 23 healthy controls June 2007-June 2009 Depression (no score, reported in the chart) SSRI (4 types) - Cord blood from the child. Methylation array and candidate gene analysis: Illumina Human Methylation450 BeadChip: Site-by-site Regional clusters Pyrosequencing Gene ontology
Gurnot, C. et al. (2015) [29] Women recruited as part of a study of psychotropic medication use during and following pregnancy. Canada 44 women (91 in the cohort): Array analysis: - 12 SRI-exposed depressed - 11 controls (depressed/non-depressed). Pyrosequencing: - 17 SRI-exposed, depressed. - 25 controls (depressed/ non-depressed). Missing Maternal mood: - HAM-D Drug levels: - Measured in the maternal blood. - Cord blood from the child. Methylation array: Illumina Infinium HumanMethylation27 array. Pyrosequencing: Verification of the methylation status of the CYP2E1 gene (found in array).
  1. AD antidepressant medication
  2. aSCOR (Specialized Center of Research for Sex and Gender Effects) or TRCBS (Translational Research Center for Behavioral Science, tertiary referral center for treatment of perinatal psychiatric illness).bEmory Women’s Mental Health Program (WMPH). cBoth studies use the same cohort with different outcome measures