Fig. 1From: Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsyHistogram of genome-wide DNA methylation array data showing frequency of methylation levels across the genome in patients with ADCA-DN (black) and controls (grey). Patients with ADCA-DN showed a lower frequency of CpGs with 0–10 % methylation and 80–95 % methylation and a concomitant increase in sites with 10–30 % methylation and >95 % methylation. This pattern suggests an increase in methylation of normally unmethylated regions, such as promoters and CpG islands, as well as further methylation of normally hypermethylated gene bodies and intergenic regionsBack to article page