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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy

Fig. 1

Histogram of genome-wide DNA methylation array data showing frequency of methylation levels across the genome in patients with ADCA-DN (black) and controls (grey). Patients with ADCA-DN showed a lower frequency of CpGs with 0–10 % methylation and 80–95 % methylation and a concomitant increase in sites with 10–30 % methylation and >95 % methylation. This pattern suggests an increase in methylation of normally unmethylated regions, such as promoters and CpG islands, as well as further methylation of normally hypermethylated gene bodies and intergenic regions

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