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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

Fig. 3

Quantitative RT-PCR analysis of candidate genes in purified monocytes and neutrophils from AAV patients and health controls. a Quantitative RT-PCR was performed on RNA isolated from monocytes of AAV patients (n = 10, black ovals) and healthy controls (HC; n = 15, light gray ovals). Expression is reported as a relative fold change for EHMT1 (ANCA 0.55 ± 0.08 versus HC 0.63 ± 0.09, p = 0.0213), EHMT2 (ANCA 0.88 ± 0.19 versus HC 1.15 ± 0.35, p = 0.0043), MSL1 (ANCA 0.21 ± 0.07 versus HC 0.25 ± 0.07, p = 0.192), and ING4 (ANCA 0.64 ± 0.12 versus HC 0.80 ± 0.29, p = 0.102). b Quantitative RT-PCR was performed on RNA isolated from neutrophils of AAV patients (n = 12, black ovals) and healthy controls (HC; n = 15, light gray ovals). Expression is reported as a relative fold change for EHMT1 (ANCA 0.80 ± 0.22 versus HC 0.95 ± 0.21, p = 0.0481), EHMT2 (ANCA 0.28 ± 0.16 versus HC 0.40 ± 0.13, p = 0.0043), MSL1 (ANCA 3.35 ± 0.74 versus HC 2.55 ± 0.63, p = 0.0157), and ING4 (ANCA 0.98 ± 0.19 versus HC 1.08 ± 0.18, p = 0.180). (Note: the median expression value is represented by the line in the box of the box and whisker plot, while mean ± standard deviation is listed in figure legend)

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