Gene | AHRR | CPOX | F2RL3 | GFI1 | GPR15 | PAICS | PAK2 |
---|---|---|---|---|---|---|---|
CpG | cg05575921 | cg02657160 | cg03636183 | cg09935388 | cg19859270 | cg13086586 | cg02319016 |
Leukocyte population | |||||||
Whole blood (n = 10, each group) | |||||||
NS (%)a | 89.8 ± 5.9 | 85.5 ± 2.7 | 77.1 ± 8.6 | 66.6 ± 4.9 | 93.9 ± 1.3 | 12.7 ± 1.6 | 91.3 ± 3.7 |
S (%)a | 68.2 ± 8.3 | 83.4 ± 2.0 | 71.8 ± 6.9 | 62.2 ± 3.7 | 92.9 ± 1.0 | 13.9 ± 1.9 | 90.0 ± 2.2 |
∆meth (%)d | −21.6 (−14.8; −28.4) | −2.1 (0.1; −4.3) | −5.3 (0.4; −10.9) | −4.4 (−0.3; −8.5) | −1.0 (0.1; −2.1) | 1.2 (2.8; −0.4) | −1.3 (1.6; −4.2) |
p valueb | 2.8E−04 | 6.0E−02 | 6.6E−02 | 3.6E−02 | 4.7E−02c | 1.4E−01 | 3.5E−01 |
Granulocyte (n = 10, each group) | |||||||
NS (%)a | 85.2 ± 7.3 | 85.3 ± 1.4 | 75.4 ± 5.5 | 52.9 ± 5.8 | 96.0 ± 0.5 | 12.4 ± 1.3 | 93.0 ± 1.5 |
S (%)a | 30.0 ± 7.0 | 84.6 ± 1.7 | 66.7 ± 4.2 | 41.7 ± 7.3 | 95.8 ± 0.6 | 11.8 ± 2.8 | 92.3 ± 2.5 |
∆meth (%)d | −55.2 (−48.5; −61.9) | −0.7 (0.8; −2.2) | −8.7 (−3.9; −13.5) | −11.2 (−5.0; −17.4) | −0.2 (0.3; −0.7) | −0.6 (1.5; −2.7) | −0.7 (1.2; −2.6) |
p valueb | 1.2E−12 | 3.3E−01 | 1.3E−03 | 1.3E−03 | 4.3E−01c | 1.0E+00c | 4.5E−01 |
PBMC (n = 6, each group) | |||||||
NS (%)a | 92.2 ± 3.3 | 84.3 ± 1.6 | 82.0 ± 3.2 | 86.2 ± 2.9 | 93.0 ± 1.1 | 11.3 ± 3.1 | 87.2 ± 3.2 |
S (%)a | 76.5 ± 5.2 | 80.0 ± 2.2 | 84.5 ± 8.1 | 83.8 ± 3.2 | 88.8 ± 3.1 | 12.5 ± 3.0 | 86.7 ± 0.5 |
∆meth (%)d | −15.7 (−10.0; −21.3) | −4.3 (−1.8; −6.8) | 2.5 (10.4; −5.4) | −2.3 (1.6; −6.2) | −4.2 (−1.2; −7.1) | 1.2 (5.1; −2.8) | −0.5 (2.4; −3.4) |
p valueb | 5.0E−03c | 3.0E−03 | 5.0E−01 | 2.1E−01 | 9.4E−03c | 4.6E−01c | 3.7E−01c |
CD3+GPR15− T cell (n = 6, each group) | |||||||
NS (%)a | 93.7 ± 2.1 | 84.5 ± 1.4 | 85.5 ± 6.6 | 87.7 ± 3.7 | 95.2 ± 1.5 | 11.7 ± 3.3 | 83.0 ± 3.5 |
S (%)a | 90.0 ± 2.2 | 81.3 ± 2.7 | 86.0 ± 6.8 | 88.5 ± 2.1 | 92.7 ± 2.0 | 13.2 ± 5.2 | 80.7 ± 4.2 |
∆meth (%)d | −3.7 (−0.9; −6.4) | −3.2 (−0.4; −5.9) | 0.5 (9.1; −8.1) | 0.8 (4.7; −3.0) | −2.5 (−0.3; −4.7) | 1.5 (7.1; −4.1) | −2.3 (2.7; −7.3) |
p valueb | 1.4E−02 | 2.7E−02 | 9.0E−01 | 6.4E−01 | 3.2E−02 | 5.6E−01 | 3.2E−01 |
CD3+GPR15+ T cell (n = 6, each group) | |||||||
NS (%)a | 91.3 ± 1.9 | 74.8 ± 3.8 | 83.7 ± 6.6 | 87.5 ± 1.4 | 55.2 ± 9.4 | 12.8 ± 3.4 | 78.5 ± 4.8 |
S (%)a | 78.7 ± 5.0 | 59.0 ± 1.3 | 86.2 ± 6.8 | 88.7 ± 2.5 | 41.3 ± 7.4 | 17.2 ± 8.6 | 68.5 ± 6.4 |
∆meth (%)d | −12.7 (−7.8;−17.6) | −15.8 (−12.2;−19.4) | 2.5 (11.1;−6.1) | 1.2 (3.8;−1.4) | −13.8 (−3.0;−24.7) | 4.3 (12.7;−4.0) | −10.0 (−2.7;−17.3) |
p valueb | 1.8E−04 | 2.0E−06 | 5.1E−01c | 3.4E−01 | 1.8E−02 | 2.2E−01c | 1.2E−02 |