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Table 3 Model A: logistic regression investigating an association between placental DNA methylation and GDM; model B: logistic regression investigating an association between placental DNA methylation grouped into the fifth quintile (n = 206) versus quintiles 1–4 (n = 824) and GDM

From: Increased global placental DNA methylation levels are associated with gestational diabetes

Model A

Constant −8.647 ± 1.589; p < 0.0001

B

S.E.

Sig.

Exp(B)

95 % CI for Exp(B)

Lower

Upper

 Maternal age, years

0.061

0.026

0.017

1.063

1.011

1.118

 BMI beginning of pregnancy, kg/m2

0.067

0.025

0.008

1.069

1.018

1.124

 S/p 2 or more miscarriages, %

−0.128

0.502

0.798

0.880

0.329

2.351

 Ethnicity (Caucasian, other)

−0.111

0.558

0.842

0.895

0.300

2.669

 Diabetes in family (yes/no)

−0.318

0.289

0.271

0.728

0.413

1.281

 Placental DNA methylation, %

0.879

0.267

0.001

2.408

1.427

4.063

Model B

Constant −5.240 ± 1.275; p < 0.0001

B

S.E.

Sig.

Exp(B)

95 % CI for Exp(B)

Lower

Upper

 Maternal age, years

0.061

0.026

0.017

1.063

1.011

1.118

 BMI beginning of pregnancy, kg/m2

0.073

0.025

0.004

1.076

1.024

1.13

 S/p 2 or more miscarriages, (%)

−0.143

0.501

0.775

0.867

0.325

2.314

 Ethnicity (Caucasian, other)

−0.139

0.554

0.802

0.87

0.294

2.579

 Diabetes in family (yes/no)

−0.314

0.289

0.277

0.731

0.415

1.286

 Placental DNA methylation (grouped)

1.098

0.292

0.0002

2.999

1.691

5.316