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Table 2 Differentially methylated cytosines (DMCs; P < 0.05) that had a negative relationship with gene expression (FDR P < 0.05)

From: Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

  

DMC

Gene expression

  

Chr. position

Gene

Methyl difference (%)

Log fold change

Fold change

Gene region

CpG island region

chr11.64670967

ATG2A

−6.8

0.62

1.5

Promoter

InterCpG

chrX.107334934

ATG4A

−11.1

0.59

1.5

Promoter

Cpg island

chrX.107334999

ATG4A

−5.3

0.59

1.5

Promoter

Cpg island

chr21.45749947

C21orf2

−6.3

0.43

1.3

3'UTR

North shelf

chrX.30671522

GK

−31.4

0.42

1.3

5'UTR

Cpg island

chrX.30671506

GK

−14.1

0.42

1.3

5'UTR

Cpg island

chr19.5153271

KDM4B

−20.7

0.39

1.3

3'UTR

South shore

chr9.34381797

KIAA1161

−13.1

0.60

1.5

Promoter

South shore

chr4.6641531

MRFAP1

−11.2

0.70

1.6

Promoter

North shore

chr1.145609911

POLR3C

−19.7

0.47

1.4

Promoter

North shore

chrX.20286470

RPS6KA3

−15.3

0.46

1.4

Promoter

Cpg island

chr9.135231749

SETX

−16.2

0.55

1.5

Promoter

South shore

chr8.22409297

SORBS3

3.9

−0.91

−1.9

5'UTR

Cpg island

chr8.22422648a

SORBS3

5.0

−0.91

−1.9

Promoter

Cpg island

chr8.22423300

SORBS3

10.6

−0.91

−1.9

5'UTR

Cpg island

chr8.22423343

SORBS3

16.4

−0.91

−1.9

5'UTR

Cpg island

chr8.22422936

SORBS3

16.6

−0.91

−1.9

Promoter

Cpg island

chr8.22422959

SORBS3

17.1

−0.91

−1.9

Promoter

Cpg island

chr8.22422927

SORBS3

17.7

−0.91

−1.9

Promoter

Cpg island

chr8.22423332

SORBS3

20.3

−0.91

−1.9

5'UTR

Cpg island

chr8.22423092

SORBS3

24.4

−0.91

−1.9

Promoter

Cpg island

chr6.56972737

ZNF451

−4.7

0.55

1.5

3'UTR

InterCpG

  1. aThis position indicates the site validated by site specific methylation sequencing