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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

Fig. 6

Transcription factor binding analysis. a Differentially methylated cytosine (DMC) at chromosome 8 position 22,409,297 is in the 5' untranslated region of sorbin and SH3 domain containing 3 (SORBS3) variant 1. This DMC is within two binding motifs for the transcription factor specificity protein 1 (Sp1). b DMCs at chromosome 8 positions 22,422,648 and 22,422,936 are in the promoter region of SORBS3 variant 2. The DMC position 22,422,648 is within a two binding motifs for the transcription factors paired box 5 (PAX5) and tumor protein p53 (p53). The DMC position 22,422,936 is within a binding motif for the transcription factor activating enhancer-binding protein 2-alpha (AP-2 Alpha). c DMCs at chromosome 8 positions 22,423,300, 22,423,332, and 22,423,343 are in the 5' untranslated region of SORBS3 variant 2. The DMC position 22,423,300 is within the binding motif for the transcription factor retinoid X receptor, alpha (RXR-alpha). The DMC positions 22,423,332 and 22,423,343 are both within binding motifs for the transcription factor GC binding factor (GCF). d The SORBS3 differentially methylated region (DMR) is located at chromosome 8 position 22,423,529–22,423,569 is in the 5' untranslated region of variant 2. On the forward strand, position 22,423,554 is within a binding motif for signal transducer and activator of transcription 4 (STAT4) and positon 22,423,560 is within the binding motif of enkephalin transcription factor 1 (ENKTF-1), E2F transcription factor 1 (E2F-1), and GC binding factor (GCF). On the reverse strand, position 22,423,555 is within the binding motif of E2F-1 and STAT4

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