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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Combinatorial epigenetic therapy in diffuse large B cell lymphoma pre-clinical models and patients

Fig. 1

Effect of the combination vorinostat with decitabine on DLBCL cells. a Scatter plots of the GI50 values of vorinostat (VST, left) and decitabine (DAC, right) in a panel of 27 DLBCL cell lines obtained at initial diagnosis or at relapse. b Isobologram for Toledo, Farage, OCI-Ly1, WSU-NHL, OCI-Ly7, and SU-DHL4, tested for the combination of DAC and VST. Circles represent each cell line with their relative position to the additive line indicating the result from the combination. Cells below the line indicate a synergistic effect. c DLBCL tumor growth curves (shown as area under the curve) in SU-DHL4 (left) and OCI-Ly7-xenografted (right) mice treated with vehicle, VST, DAC, or VST + DAC

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