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Table 1 Studied histone-modifying complexes sorted by identification strategies

From: Studying epigenetic complexes and their inhibitors with the proteomics toolbox

 

Identification strategy

Protein complex

Immobilized drug

Antibody against protein complex constituent

Antibody against epitope tags

Recombinant tags other than epitope taps

Bait (histone) tail peptide

Writer

 HAT

  

[82]

[99, 100]

 

 PMT

[56]

 

[84, 87]

[102, 105, 129]

[120]

Eraser

 HDAC

[20, 23, 29, 31, 63, 130]

[20, 70]

[88, 92, 109]

[131]

 

 Lysine demethylases

[52]

 

[85]

[71, 107]

[119]

 Lysine decrotonylase

    

[117]

Reader

 BET

[63, 39]

[39]

[94]

[108]

[39]

 Methyl-lysine- and/or methyl-arginine binding domain-containing protein

   

[76, 103, 110]

[76, 112, 113, 115]

 PHD-containing proteins

  

[95]

[81, 101]

[116]

 Phosphor-threonine/phosphor-serine binding protein

[111]

   

[111, 118]

  1. HAT histone acetyl transferase, PMT protein methyl transferase, HDAC histone deacetylase, BET bromodomain and extraterminal domain family, PHD plant homodomain
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Clinical Epigenetics

ISSN: 1868-7083

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