Skip to main content

Table 2 Candidate genes involved in DNA methylation, demethylation, and one-carbon metabolism, for which expression changes were significantly correlated with chemosensitivity or chemoresistance to drug agents

From: Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment

Gene

Antitumor agent

Drug concentration and time after treatment

r

FDR adjusted p value

FOLR2

Doxorubicin

High, 24 h

−0.509

0.0366

SMUG1

Doxorubicin

Low, 24 h

−0.488

0.0284

GART

Paclitaxel

Low, 24 h

0.462

0.0422

GADD45A

Cisplatin

High, 24 h

−0.618

0.0011

GADD45A

Cisplatin

Low, 24 h

−0.477

0.0422

MBD1

Cisplatin

High, 24 h

−0.570

0.0046

MTR

Cisplatin

High, 24 h

0.564

0.0046

MTHFD1

Cisplatin

High, 24 h

0.552

0.0061

CTH

Cisplatin

High, 24 h

−0.531

0.0122

CTH

Cisplatin

Low, 24 h

−0.504

0.0234

  1. Listed are genes involved in DNA methylation, demethylation, and the OCM pathway which satisfied FDR adjusted p <0.05 for Pearson correlation of their expression changes with chemosensitivity
  2. r Pearson coefficient of correlation of log2 FC with log(GI50) values across NCI-60 cell lines