DNA methylation levelsa
| NGT mother | GDM mother |
p
|
---|
|
n = 100 |
n = 33 | |
---|
PRDM16-CpG1 | 29.4 ± 14.1 | 26.9 ± 9.2 | 0.93 |
PRDM16-CpG2 | 33.7 ± 13.9 | 29.2 ± 14.7 | 0.12 |
PRDM16-CpG3 | 43.8 ± 13.7 | 38.8 ± 15.6 |
0.08
|
PRDM16-CpG4 | 23.5 ± 10.4 | 22.2 ± 13.0 | 0.24 |
Mean BMP7
| 29.9 ± 6.9 | 27.4 ± 4.8 |
0.03
|
Mean CTBP2
| 13.8 ± 1.4 | 13.7 ± 2.4 | 0.54 |
MeanPPARGC1α-CpG1,2b, c
| 12.1 ± 8.2 | 10.4 ± 5.7 | 0.78 |
PPARGC1α-CpG3 | 46.7 ± 15.0 | 49.8 ± 13.9 | 0.17 |
PPARGC1α-CpG4 | 51.0 ± 12.5 | 55.2 ± 13.5 |
0.09
|
-
aResidual scores of DNA methylation levels were used in the statistical models. They were obtained by using unstandardized analysis of residuals computed by linear regressions which included gestational age, newborn’s sex and weight, smoking during pregnancy, weight gain between the first and second trimester and maternal BMI at the first trimester
-
b
n = 129 (70 normal weight and 59 overweight)
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c
n = 129 (96 NGTs and 33 GDMs). Statistically significant results (p < 0.05) are shown in bold, whereas statistical trend (p < 0.10) are shown in italics