Table 2 Spearman’s correlation coefficients between placental DNA methylation and metabolic variables of mothers (second and third trimester of pregnancy)—E-21 birth cohort
2nd trimester | 3rd trimester | ||||||
|---|---|---|---|---|---|---|---|
DNA methylation levelsa | Fasting glucose levels | Fasting insulin levels | 2 h post-OGTT glucose levels | HOMA-IR | Fasting glucose levels | Fasting insulin levels | HOMA-IR |
n = 130 | n = 125 | n = 133 | n = 122 | n = 133 | n = 133 | N = 116 | |
PRDM16-CpG1 | r = −0.04 | r = −0.18 | r = −0.05 | r = −0.17 | r = 0.02 | r = −0.09 | r = −0.088 |
NS | p = 0.05 | NS | p = 0.05 | NS | NS | NS | |
PRDM16-CpG2 | r = −0.14 | r = −0.13 | r = −0.04 | r = −0.15 | r = 0.24 | r = 0.101 | r = 0.162 |
p = 0.12 | p = 0.14 | NS | p = 0.10 | p = 0.007 | NS | p = 0.08 | |
PRDM16-CpG3 | r = −0.18 | r = −0.05 | r = −0.04 | r = −0.08 | r = 0.10 | 0.13 | r = 0.106 |
p = 0.04 | NS | NS | NS | NS | NS | NS | |
PRDM16-CpG4 | r = −0.13 | r = −0.04 | r = −0.06 | r = −0.06 | r = 0.09 | r = 0.03 | r = 0.042 |
p = 0.15 | NS | NS | NS | NS | NS | NS | |
Mean BMP7 | r = −0.09 | r = −0.09 | r = −0.18 | r = −0.07 | r = 0.09 | r = 0.05 | r = 0.007 |
NS | NS | p = 0.04 | NS | NS | NS | NS | |
Mean CTBP2 | r = −0.15 | r = −0.13 | r = −0.02 | r = −0.17 | r = 0.06 | r = 0.08 | r = 0.056 |
p = 0.10 | p = 0.15 | NS | p = 0.06 | NS | NS | NS | |
Mean PPARGC1α-CpG1,2 | r = −0.29 | r = −0.13 | r = −0.05 | r = −0.13 | r = −0.05 | r = 0.41 | r = −0.033 |
NS | p = 0.15 | NS | p = 0.18 | NS | p < 0.001 | NS | |
PPARGC1α-CpG3 | r = 0.18 | r = −0.01 | r = 0.16 | r = 0.02 | r = 0.067 | r = 0.06 | r = 0.073 |
p = 0.05 | NS | p = 0.07 | NS | NS | NS | NS | |
PPARGC1α-CpG4 | r = 0.23 | r = 0.13 | r = 0.22 | r = 0.17 | r = 0.109 | r = 0.032 | =0.018 |
p = 0.008 | p = 0.14 | p = 0.01 | p = 0.08 | NS | NS | NS | |