Skip to main content
Fig. 3 | Clinical Epigenetics

Fig. 3

From: PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns

Fig. 3

Mediation analyses between maternal glucose levels, DNA methylation variations, and cord blood leptin concentrations. Squared numbers correspond to the coefficients for the total effect with associated p values. Path a is the relationship between maternal variables and DNA methylation levels. Path b is the relationship between DNA methylation levels and cord blood leptin levels. Path c is the indirect relationship between maternal variables and cord blood leptin levels, and c‘ is the direct effect of this relationship when taking into account the DNA methylation signature. a DNA methylation variations at the PPARGC1α - CpG3 gene locus induced by glycemia at the second trimester of pregnancy mediate cord blood leptin levels. b DNA methylation variations at the PPARGC1α - CpG4 gene locus induced by glycemia at the second trimester of pregnancy mediate cord blood leptin levels. c The mediation effect of DNA methylation variations at the PRDM16 - CpG2 gene locus was demonstrated between maternal glycemia at the third trimester of pregnancy and cord blood leptin levels

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us