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Fig. 1 | Clinical Epigenetics

Fig. 1

From: PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns

Fig. 1

Maternal glycemia correlations with cord blood leptin levels. Maternal glycemia was correlated with cord blood leptin levels. a Fasting glucose at second trimester; b third trimester of pregnancy and c HOMA-IR at the second trimester of pregnancy were correlated with cord blood leptin levels. Unstandardized residuals were first computed for DNA methylation levels using linear regression and gestational age, newborn’s sex and weight, smoking during pregnancy, weight gain between the first and second trimester of pregnancy and maternal BMI at the first trimester of pregnancy as covariates. The residuals were then used to compute Spearman’s correlation coefficients

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