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Table 1 Differentially methylated regions (DMR). Shown are the DMRs with the significance level p < 0.05 as reported by the bumphunter software and spanning at least three CpGs with the average DNA methylation differences (delta beta) between IUGR and healthy twins above 10 % by magnitude in all CpGs. The DMRs are sorted by the magnitude of delta-beta differences. DMR length is measured in basepairs. Gene matches represent the overlaps between the DMR and the gene’s body or promoter region up to 1500 bp from the transcription start site. Genome coordinates are given with respect to hg19 genome assembly

From: Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction

Chr

Start

End

Δβ

p value

CpGs

Length

Gene

8

91013426

91013697

0.175

0.0027

6

272

DECR1

5

150284416

150284796

0.161

0.0032

7

381

ZNF300

15

78556834

78556945

−0.152

0.0082

5

112

DNAJA4

5

43396953

43397288

−0.139

0.0081

6

336

CCL28

1

65991176

65991664

0.133

0.0329

3

489

LEPR

6

31783322

31783482

0.130

0.0069

7

161

HSPA1A/L

10

106014615

106014893

0.126

0.0401

3

279

GSTO1

9

36258114

36258885

0.120

0.0114

6

772

GNE