Fig. 2

DNAm changes in IUGR twins in DECR1 promoter. Methylation levels in IUGR twins (orange circles) and unaffected co-twins (blue crosses) are shown, arranged vertically for each CpG in the region spanning the DECR1 gene promoter. The mean methylation levels are shown for the IUGR cohort (red line) and controls (blue line). The top six CpGs with methylation change above 10 %, and no more than 500 bp apart, comprise the DMR (red box), which also corresponds to the wider gap between the red and blue lines. Other genomic features, such as CpG islands, histone marks, DNase hypersensitivity clusters, and transcription factor binding sites are also shown. Visualization is provided by the UCSC Genome Browser and was inspired by DMRcate software [66]