From: Combined clinical and genetic testing algorithm for cervical cancer diagnosis
Target genes | Cutoff | Sensitivity (%) (95 % CI) | Specificity (%) (95 % CI) | AUC (%) (95 % CI) | Odds ratio (95 % CI) | P value |
---|---|---|---|---|---|---|
CIN3+ lesion | ||||||
Algorithm 1 | 220 | 89.87 (84.18–93.67) | 75.95 (70.72–80.50) | 82.9 (78.9–86.9) | 28.02 (15.65–50.17) | <0.001 |
Algorithm 2 | 220 | 86.08 (79.82–90.62) | 80.76 (75.84–84.87) | 83.4 (79.3–87.5) | 25.94 (15.17–44.36) | <0.001 |
Algorithm 3 | 220 | 92.41 (87.19–95.60) | 72.51 (67.11–77.32) | 82.5 (78.5–86.4) | 32.09 (16.88–61.00) | <0.001 |
CIS/SCC/AC | ||||||
Algorithm 1 | 220 | 96.51 (90.24–98.81) | 64.46 (59.41–69.21) | 78.8 (74.2–83.5) | 50.19 (15.55–161.98) | <0.001* |
Algorithm 2 | 220 | 100.0 (94.87–100.0) | 70.80 (65.92–75.24) | 84.0 (80.4–87.6) | – | – |
Algorithm 3 | 220 | 100.0 (94.87–100.0) | 61.43 (56.33–66.30) | 79.5 (75.3–83.7) | – | – |