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Table 3 Crude and adjust odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) for predictors of CIN3+ in cervical cancer

From: Combined clinical and genetic testing algorithm for cervical cancer diagnosis

 

Odds ratio (95 % CI)

Variable

Number

Crude

P value

Adjusted

P value

Age group

<30

52

Reference

 

Reference

 

30–50

319

3.93 (1.72–9.00)

0.001

2.97 (1.13–7.80)

0.027

>50

78

4.02 (1.61–10.06)

0.003

2.13 (0.68–6.69)

0.194

No. of pregnancies

0

24

Reference

   

1~3

232

2.68 (0.89–8.11)

0.081

  

>3

193

3.04 (1.00–9.25)

0.050

  

No. of births

0

46

Reference

 

Reference

 

1~3

363

2.24 (1.05–4.79)

0.038

1.06 (0.43–2.63)

0.895

>3

40

4.54 (1.75–11.83)

0.002

1.71 (0.53–5.56)

0.370

Intrauterine device (IUD) usage

No

215

Reference

   

Yes

234

1.41 (0.95–2.08)

0.087

  

Condom usage

No

336

Reference

 

Reference

 

Yes

113

0.59 (0.37–0.94)

0.027

0.78 (0.46–1.31)

0.349

Oral contraception usage

No

391

Reference

   

Yes

58

0.81 (0.45–1.46)

0.478

  

Tubal ligation

No

360

Reference

   

Yes

89

0.98 (0.60–1.60)

0.937

  

Gynecology history: cervical contact bleeding

No

329

Reference

 

Reference

 

Yes

120

1.61 (1.05–2.47)

0.030

1.11 (0.68–1.80)

0.673

Gynecology history: vaginal bleeding

No

385

Reference

 

Reference

 

Yes

64

3.77 (2.18–6.54)

<0.001

2.95 (1.62–5.39)

<0.001

Gynecology history: abnormal vaginal discharge

No

439

Reference

   

Yes

10

1.87 (0.53–6.56)

0.329

  

Gynecologic examination: grossly normal cervix

No

323

Reference

 

Reference

 

Yes

126

0.40 (0.25–0.65)

<0.001

0.51 (0.30–0.85)

0.011

Gynecologic examination : cervical erosion

No

196

Reference

   

Yes

253

1.00 (0.68–1.48)

0.995

  

Gynecologic examination: cervical mass

No

349

Reference

 

Reference

 

Yes

100

2.01 (1.28–3.15)

0.003

1.37 (0.83–2.25)

0.220

Gynecologic examination: ulcer

No

446

Reference

   

Yes

3

3.72 (0.33–41.33)

0.285

  

Gynecologic examination: contact bleeding

No

403

Reference

 

Reference

 

Yes

46

2.95 (1.58–5.50)

0.001

1.94 (0.99–3.83)

0.055