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Table 2 Performance of methylated genes and HPV tests for CIN3+ detection

From: Combined clinical and genetic testing algorithm for cervical cancer diagnosis

Tests Sensitivity (%) (95 % CI) Specificity (%) (95 % CI) AUC (%) (95 % CI) Odds ratio (95 % CI) P value
PAX1 m 69.62 (62.05–76.26) 81.79 (76.95–85.80) 75.5 (70.8–80.6) 10.29 (6.55–16.16) <0.001
ZNF582 m 76.58 (69.40–82.51) 86.94 (82.58–90.34) 81.8 (77.3–86.2) 21.77 (13.18–35.96) <0.001
PAP 68.99 (61.40–75.68) 90.72 (86.84–93.54) 79.9 (75.1–84.6) 21.75 (12.93–36.59) <0.001
hrHPV 98.10 (94.57–99.35) 46.05 (40.41–51.79) 72.1 (67.5–76.7) 44.10 (13.75–141.45) <0.001*
HPV-16/18 65.19 (57.48–72.18) 87.63 (83.35–90.93) 76.4 (71.4–81.4) 13.27 (8.22–21.40) <0.001
PAX1 m or hrHPV 98.73 (95.50–99.65) 42.61 (37.06–48.35) 70.7 (66.0–75.3) 57.92 (14.09–238.17) <0.001*
PAX1 m or HPV-16/18 89.24 (83.45–93.17) 75.95 (70.72–80.50) 82.6 (78.5–86.6) 26.19 (14.80–46.33) <0.001
PAX1 m or ZNF582 m 85.44 (79.10–90.10) 76.98 (71.81–81.44) 81.2 (76.9–85.5) 19.62 (11.67–32.99) <0.001
ZNF582 m or hrHPV 98.73 (95.50–99.65) 45.02 (39.40–50.76) 71.9 (67.3–76.5) 63.86 (15.53–262.56) <0.001*
ZNF582 m or HPV-16/18 85.44 (79.10–90.10) 81.10 (76.21–85.18) 83.3 (79.2–87.4) 25.19 (14.82–42.82) <0.001
  1. P value determined by chi-squared test and *Fisher’s exact test; odds ratio for CIN3+
  2. CI confidence interval, HPV human papillomavirus, hrHPV high-risk human papillomavirus, Gene m methylated gene