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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

Fig. 3

Identification of ERCC6 minimal promoter. a Schematic illustration of deletion constructs of ERCC6 proximal promoter pGL3 -603/-396, Met-pGL3 -466/-396, pGL3 control, and pGL3 enhancer. b Luciferase activity of the deleted constructs in 293T cells. Data are expressed as mean ± SD of three independent experiments. The thick lines represent retained parts of overall length (from -466 to -396, relative to the TSS). The dash lines represent the removed parts of overall length. The thin lines only represent the link to plasmid. Met-pGL3 -466/-396 represents methylated pGL3 -466/-396 without changing the sequences

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Clinical Epigenetics

ISSN: 1868-7083

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