Skip to main content
Fig. 2 | Clinical Epigenetics

Fig. 2

From: Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

Fig. 2

Methylation status of the CpG island at promoter of ERCC6 in LECs of controls and ARNCs (30 controls and 30 ARNCs, the samples cover those analyzed in Fig. 1). a The CpG island (-603/-396, black arrow) located in the promoter of ERCC6. There are twelve CpG sites (the red marker letter) and a putative binding site for Sp1 (-446/-437) relative to transcriptional starting site (red arrow) in the region. b In LECs of ARNCs, the CpG site 8 displayed hypermethylation compared to the controls. *P < 0.01. c Representative pyrosequencing results of the ARNC. d Representative pyrosequencing results of the control

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us