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Fig. 10 | Clinical Epigenetics

Fig. 10

From: Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

Fig. 10

UVB irradiation decreased the occupancy of endogenous Sp1 and H3K9 acetylation on the ERCC6 promoter, but increased occupancy of DNMT3b and HDAC1 on the ERCC6 promoter. a HLE-B3 cells were treated with UVB irradiation. ChIP was performed using anti-Sp1, anti-DNMT3b, anti-HDAC1, and anti-ac-H3 (K9). b Statistically significant differences from control cells were indicated by *(P < 0.01)

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Clinical Epigenetics

ISSN: 1868-7083

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