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Table 2 Associations of differences between Δage (per 5 years) according to different predictors of DNAmage with all-cause and cause-specific mortality

From: Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

Causes of death
(N of events; %)
Predictor Cox model 1a
(Hazard ratios)
Cox model 2b
(Hazard ratios)
All-cause mortality    
 (602; 32.3) DNAmage (Horvath) 1.22 (1.10–1.36) 1.23 (1.10–1.38)
 (602; 32.3) DNAmage (Hannum) 1.16 (1.00–1.34)* 1.10 (0.94–1.29)
Cancer mortality    
 (235; 12.6) DNAmage (Horvath) 1.20 (1.03–1.39) 1.22 (1.03–1.45)
 (235; 12.6) DNAmage (Hannum) 1.08 (0.87–1.35) 1.03 (0.80–1.33)
Cardiovascular disease mortality    
 (194; 10.4) DNAmage (Horvath) 1.20 (1.02–1.42) 1.19 (0.98–1.43)
 (194; 10.4) DNAmage (Hannum) 1.13 (0.89–1.44) 1.00 (0.79–1.29)
  1. *p = 0.0408
  2. aModel 1: adjusted for chronological age (continuous), sex, batch effects, and leucocyte distribution
  3. bModel 2: additionally adjusted for educational level, history of cancer diseases, history of CVD, hypertension, diabetes mellitus, smoking status (never/former vs. current), and body mass index (continuous)