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Table 2 Associations of differences between Δage (per 5 years) according to different predictors of DNAmage with all-cause and cause-specific mortality

From: Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

Causes of death

(N of events; %)

Predictor

Cox model 1a

(Hazard ratios)

Cox model 2b

(Hazard ratios)

All-cause mortality

   

 (602; 32.3)

DNAmage (Horvath)

1.22 (1.10–1.36)

1.23 (1.10–1.38)

 (602; 32.3)

DNAmage (Hannum)

1.16 (1.00–1.34)*

1.10 (0.94–1.29)

Cancer mortality

   

 (235; 12.6)

DNAmage (Horvath)

1.20 (1.03–1.39)

1.22 (1.03–1.45)

 (235; 12.6)

DNAmage (Hannum)

1.08 (0.87–1.35)

1.03 (0.80–1.33)

Cardiovascular disease mortality

   

 (194; 10.4)

DNAmage (Horvath)

1.20 (1.02–1.42)

1.19 (0.98–1.43)

 (194; 10.4)

DNAmage (Hannum)

1.13 (0.89–1.44)

1.00 (0.79–1.29)

  1. *p = 0.0408
  2. aModel 1: adjusted for chronological age (continuous), sex, batch effects, and leucocyte distribution
  3. bModel 2: additionally adjusted for educational level, history of cancer diseases, history of CVD, hypertension, diabetes mellitus, smoking status (never/former vs. current), and body mass index (continuous)