Skip to main content

Table 1 Sirtuin location, activity, and effects on pathologies

From: Sirtuin functions and modulation: from chemistry to the clinic

Sirtuin

Localization

Enzymatic activity

Histone deacetylation target

Non-histone deacetylation target

Pathology

SIRT1

Nuclear/cytoplasmatic

Deacetylase

H3K9ac

Hif-1α, Hif-2α

Neurodegenerative diseases. Cancer: acute myeloid leukemia, colon, prostate, ovarian, glioma, breast, melanoma, lung adenocarcinoma.

H1K26ac

MYC

H4K16ac

SIRT2

Nuclear/cytoplasmatic

Deacetylase

H3K56ac

Tubulin

Neurodegenerative diseases. Cancer: brain tissue, glioma.

H4K16ac

Foxo3a

 

EIF5A

P53, G6PD, MYC

SIRT3

Mitochondrial

Deacetylase

H3K56ac

SOD2, PDMC1a, IDH2, GOT2, FoxO3a

Neurodegenerative diseases. Cancer: B cell chronic lymphocytic leukemia, mantle cell lymphoma, chronic lymphocytic leukemia, breast, gastric.

H4K14 ac

SIRT4

Mitochondrial

ADP-ribosyltransferase

Unknown

GDH, PDH

Cancer: breast, colorectal.

SIRT5

Mitochondrial

Malonyl, succinyl, glutaryl deacetylase

Unknown

CPS1

Cancer: pancreatic, breast, non-small cell lung carcinoma.

SIRT6

Nuclear

Deacetylase, ADP-ribosyltransferase, long-chain fatty acyl deacylase

H3K9ac

Unknown

Cancer: breast, colon.

H3K56ac

SIRT7

Nuclear

Deacetylase

H3K18ac

Hif-1α, Hif-2α

Cancer: liver, testis, spleen, thyroid, breast.