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Table 1 Sirtuin location, activity, and effects on pathologies

From: Sirtuin functions and modulation: from chemistry to the clinic

Sirtuin Localization Enzymatic activity Histone deacetylation target Non-histone deacetylation target Pathology
SIRT1 Nuclear/cytoplasmatic Deacetylase H3K9ac Hif-1α, Hif-2α Neurodegenerative diseases. Cancer: acute myeloid leukemia, colon, prostate, ovarian, glioma, breast, melanoma, lung adenocarcinoma.
H1K26ac MYC
H4K16ac
SIRT2 Nuclear/cytoplasmatic Deacetylase H3K56ac Tubulin Neurodegenerative diseases. Cancer: brain tissue, glioma.
H4K16ac Foxo3a
  EIF5A
P53, G6PD, MYC
SIRT3 Mitochondrial Deacetylase H3K56ac SOD2, PDMC1a, IDH2, GOT2, FoxO3a Neurodegenerative diseases. Cancer: B cell chronic lymphocytic leukemia, mantle cell lymphoma, chronic lymphocytic leukemia, breast, gastric.
H4K14 ac
SIRT4 Mitochondrial ADP-ribosyltransferase Unknown GDH, PDH Cancer: breast, colorectal.
SIRT5 Mitochondrial Malonyl, succinyl, glutaryl deacetylase Unknown CPS1 Cancer: pancreatic, breast, non-small cell lung carcinoma.
SIRT6 Nuclear Deacetylase, ADP-ribosyltransferase, long-chain fatty acyl deacylase H3K9ac Unknown Cancer: breast, colon.
H3K56ac
SIRT7 Nuclear Deacetylase H3K18ac Hif-1α, Hif-2α Cancer: liver, testis, spleen, thyroid, breast.