DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Cao-Lei, Lei; Veru, Franz; Elgbeili, Guillaume; Szyf, Moshe; Laplante, David P.; King, Suzanne

doi:10.1186/s13148-016-0219-0

Table 4 Significant mediating effects of gene methylation on IL-4 outcome

From: DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Gene	CpG site	DNA methylation				IL-4 outcome							Mediation effect
		R ²	Storm32			R ²	DNA methylation			Storm32			Mediation effect
		R ²	Effect (a)	SE	p val.	R ²	Effect (b)	SE	p val.	Effect (c')	SE	p val.	Effect (ab*)	Boot SE	Boot LLCI	Boot ULCI	Standardized effect
BCL10	cg01636910	0.1332	−0.0506	0.0232	0.0367	0.2035	−0.2347	0.1441	0.1139	0.0297	0.0200	0.1466	0.0119	0.0091	0.0006	0.0368	0.104041
IGF1R	cg13297560	0.1322	0.0388	0.0178	0.0375	0.2072	0.3125	0.1866	0.1044	0.0295	0.0199	0.1489	0.0121	0.0093	0.0004	0.0386	0.106277
LCK	cg17078393	0.2561	0.0659	0.0202	0.0027	0.2394	0.3308	0.1616	0.0495	0.0198	0.0211	0.3547	0.0218	0.0132	0.0037	0.0563	0.191284
LCK	cg05350315	0.1949	0.0711	0.0260	0.0101	0.2457	0.2648	0.1252	0.0428	0.0228	0.0202	0.2673	0.0188	0.0119	0.0029	0.0524	0.165089
MAP3K14	cg16826777	0.1665	−0.0516	0.0207	0.0184	0.2167	−0.2857	0.1597	0.0838	0.0269	0.0202	0.1931	0.0147	0.0093	0.0018	0.0396	0.129202
PIK3CD	cg07499142	0.1747	0.0599	0.0234	0.0155	0.2021	0.2300	0.1429	0.1178	0.0278	0.0205	0.1842	0.0138	0.0090	0.0003	0.0373	0.120821
PIK3R2	cg11953794	0.2101	−0.0753	0.0262	0.0073	0.2113	−0.2185	0.1267	0.0949	0.0252	0.0208	0.2359	0.0164	0.0105	0.0001	0.0403	0.144195
PIK3R2	cg04610450	0.1700	−0.0442	0.0176	0.0171	0.2008	−0.3036	0.1904	0.1214	0.0282	0.0204	0.1780	0.0134	0.0094	0.0003	0.0389	0.117742
PRKCZ	cg02481000	0.1183	−0.0434	0.0213	0.0501	0.2340	−0.3056	0.1538	0.0560	0.0283	0.0194	0.1546	0.0133	0.0099	0.0007	0.0412	0.11632
TLR6	cg14578677	0.1978	−0.0707	0.0256	0.0095	0.2094	−0.2213	0.1301	0.0992	0.0260	0.0207	0.2187	0.0156	0.0116	0.0008	0.0470	0.137144
TNFRSF1B	cg05599723	0.1221	−0.0465	0.0224	0.0462	0.2060	−0.2470	0.1488	0.1075	0.0301	0.0198	0.1387	0.0115	0.0086	0.0003	0.0350	0.100689
ZAP70	cg08859278	0.1844	0.0475	0.0179	0.0126	0.2172	0.3310	0.1844	0.0828	0.0259	0.0204	0.2142	0.0157	0.0093	0.0019	0.0405	0.137839

None of the mediation effects survived Bonferroni correction

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ISSN: 1868-7083

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