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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Fig. 1

NF-κB signaling pathway with genes associated with objective PNMS. Among the 20 genes selected from NF-κB signaling pathway, DDR1, FLT1, IGF1R, IL1R2, LCK, LTA, MAP4K4, NFKBIA, PIK3CD, TGFBR2, TNFAIP3, and ZAP70 were greater methylated; BCL10, LTBR, MAP3K14, PIK3R2, PRKCZ, TLR6 and TRAF5 were lesser methylated; TNFRSF1B was either greater or lesser methylated depending on the different CpG sites. The gene family A20 (TNFAIP3), growth factor receptor (DDR1, FLT1, IGF1R, and TGFBR2), IkB (NFKBIA), LCK, LTA, and ZAP70 are highlighted in red. The gene family BCL10, LTBR, MEKK3/NIK (MAP3K14), PRKCZ, TRAF2/3/5, and TRAF5/6 are highlighted in green. The gene family IL-1R/TLR (IL1R2 and TLR6), NIK (MAP3K14 and MAP4K4), P13K (PIK3CD and PIK3R2), and TNFR (TNFRSF1B) are highlighted in orange.

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Clinical Epigenetics

ISSN: 1868-7083

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