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Table 2 Baseline characteristics of the validation cohort

From: DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease

 

Mild fibrosis (F0-2)

Severe fibrosis (F3-6)

P value

n = 70

n = 32

Gender—malea

33 (47.1)

20 (62.5)

ns

Age (years)a

45.6 ± 13.7

50.28 ± 11.25

ns

Hbe Ag positivea

16

6

ns

Anti Hbe Ab positivea

54

26

 

HBV DNA (log IU/mL)b

7.4 ± 4.3

7.0 ± 2.5

ns

Serum ALT (IU/L)b

70.5 ± 48.0

83.0 ± 59.87

ns

Serum AST (IU/L)b

45.1 ± 22.5

64.28 ± 47.3

ns

White blood cell count (×109/L)b

6.4 ± 1.5

6.3 ± 1.7

ns

Platelet count (×109/L)b

207.7 ± 45.6

196.5 ± 42.8

ns

Haemoglobin (g/L)b

14.0 ± 1.7

14.5 ± 1.3

ns

Albumin (g/L)b,c

4.4 ± 0.3

4.4 ± 0.3

ns

Prothrombin time (s)b,c

11.4 ± 1.6

11.5 ± 2.5

ns

Conjugated bilirubin (mg/dL)b,c

0.19 ± 0.18

0.26 ± 0.25

ns

Modified histologic activity indexa

   

 0–4

47 (67.1)

1 (3.1)

 5–9

22 (31.4)

25 (78.1)

 10–14

1 (1.4)

5 (15.6)

 15–18

1 (3.1)

Fibrosisa

  

 0

33 (47.1)

 1

20 (28.5)

 2

17 (24.2)

 3

20 (62.5)

 4

5 (15.6)

 5

5 (15.6)

 6

2 (6.2)

  1. a,bData are shown as number and percentage (a) or mean and standard deviation (b). The histologic activity index is a sum of portal inflammation, confluent necrosis, focal lytic necrosis and periportal or periseptal interface hepatitis scores which was expressed on a scale of 18. Fibrosis stage was assessed on a scale of 0 to 6
  2. cInformation on conjugated bilirubin, prothrombin time and albumin was missing in six, two, and five patients, respectively