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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease

Fig. 2

Plots were demonstrated as the correlation between the CpG methylation and severity of the liver disease. The analysis compares the hepatic DNA methylation level in the Ishak fibrosis stages of F0-2 with F3-6. Horizontal bars represent the means and 95 % confidence interval. Using bisulfite modification and pyrosequencing, hepatic cytosine methylation at four loci was assessed. Changes in HDAC4 (a, b), HOXA2 (c) and PPP1R18 (d) CpG methylation are associated with severe inflammation and fibrosis in the discovery cohort

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