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Table 2 Methylation profiles in sperm from men with normal weight at the DMRs of imprinted genes

From: Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study

 

Methylation % in sperm from men with normal BMI

 

MEG3-IG

MEG3

PEG1/MEST

IGF2

H19

GRB10

NNAT

NDN

SNRPN

SGCE/PEG10

PEG3

PLAGL1

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

%

SE

CpG 1

  

0.84

0.38

0.65

0.11

91.80

0.25

95.28

0.40

0.87

0.19

0.61

0.19

1.90

0.32

2.53

0.18

3.48

0.57

1.50

0.22

4.03

0.89

CpG 2

79.02

0.48

2.68

0.53

1.20

0.08

92.90

0.36

66.71

0.93

2.81

0.17

1.90

0.25

1.26

0.34

1.59

0.16

1.91

0.58

1.62

0.25

3.90

0.91

CpG 3

73.99

0.36

1.83

0.56

2.06

0.14

96.99

0.37

92.79

0.34

1.32

0.17

2.99

0.28

1.27

0.21

1.86

0.19

3.69

0.61

1.58

0.24

4.57

0.82

CpG 4

85.85

0.46

3.10

0.51

2.35

0.19

  

95.29

0.31

1.22

0.18

  

1.54

0.31

0.74

0.15

4.25

0.56

1.19

0.21

4.20

0.91

CpG 5

80.01

0.37

1.71

0.56

      

2.75

0.16

  

1.58

0.30

  

2.63

0.59

1.70

0.27

3.99

0.86

CpG 6

  

1.89

0.56

      

2.14

0.16

  

2.10

0.25

  

4.44

0.63

1.05

0.25

3.32

0.77

CpG 7

  

2.52

0.53

                

1.91

0.24

  

CpG 8

  

2.21

0.52

                

0.92

0.22

  

CpG 9

                    

2.23

0.24

  

CpG 10

                    

1.97

0.21

  

Mean

79.72

0.33

2.10

0.51

1.56

0.08

93.90

0.28

87.51

0.34

1.85

0.16

1.83

0.26

1.61

0.28

1.65

0.16

3.40

0.58

1.57

0.23

4.00

0.84

  1. Results shown here describe methylation profiles for normal weight men (BMI < 25). The DNA methylation percentages are presented for each DMR, by the individual CpG site studied. The calculated mean for each DMR is shown on the bottom line
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Clinical Epigenetics

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