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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7

Fig. 1

Vitamin C enhances the cytotoxic effects of 5-AZA in inducing cell death in HCC. a Changes in the resazurin conversion indicating the cell viability in HLE and Huh7 cells treated with vitamin C, 5-AZA, and 5-AZA + vitamin C compared to the untreated controls after 48 h. b Changes in the LDH release by HLE and Huh7 with the various treatments compared to the untreated control. c Flow cytometric measurement of sub2N population in HLE and Huh7 treated with vitamin C, 5-AZA, and 5-AZA + vitamin C. All the data are the average of the experiments (N = 3). Statistical significance was tested using one-way ANOVA (non-parametric) Tukey’s test. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.01. Error bars represent the standard deviation

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Clinical Epigenetics

ISSN: 1868-7083

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