Fig. 2

Visualization of DMR and DMP results overlapping genomic annotations. This example figure, which was created from 450K data for peripheral blood specimens that were collected from women diagnosed with breast cancer, demonstrates how both experimental results and predicted functional elements can be viewed as individual tracks along a set of genomic coordinates (x-axis) specified along a gene (e.g., the FKBP5 gene (bottom track)). The top track displays the statistical model coefficient from a univariate test to identify individual DMPs, and the plot rug (along the x-axis) indicates significant (black tick) findings. The identified DMRs (second track) correspond to clusters of DMP results with similar coefficient values and in this example overlap CpG islands (third track) and predicted promoter regions (fourth track). These regions also correspond to other publically curated annotations that, for instance, can indicate enrichment for different chromatin states (fifth track)