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Table 2 Methylation frequency of PAX6 gene in 349 liver tissues

From: Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma

Etiology % of methylated cases (methylated cases/total) p value
Normal controls Non-tumor tissues HCC tissues
All 3.4 % (1/29) 15.6 % (25/160) 39.4 % (63/160) <0.0001
HBV 10.0 % (1/10) 17.6 % (12/68) 22.1 % (15/68) 0.3243
HCV 0.0 % (0/3) 6.5 % (4/62) 61.3 % (38/62) <0.0001
NBC 0.0 % (0/16) 30.0 % (9/30) 33.3 % (10/30) 0.0227
  1. Samples with a methylation level above the best cutoff value (MI > 1.13) were determined as methylated cases