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Table 2 Methylation frequency of PAX6 gene in 349 liver tissues

From: Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma

Etiology

% of methylated cases (methylated cases/total)

p value

Normal controls

Non-tumor tissues

HCC tissues

All

3.4 % (1/29)

15.6 % (25/160)

39.4 % (63/160)

<0.0001

HBV

10.0 % (1/10)

17.6 % (12/68)

22.1 % (15/68)

0.3243

HCV

0.0 % (0/3)

6.5 % (4/62)

61.3 % (38/62)

<0.0001

NBC

0.0 % (0/16)

30.0 % (9/30)

33.3 % (10/30)

0.0227

  1. Samples with a methylation level above the best cutoff value (MI > 1.13) were determined as methylated cases