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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Quantitative methylation analysis reveals distinct association between PAX6 methylation and clinical characteristics with different viral infections in hepatocellular carcinoma

Fig. 3

Methylation levels and ROC curve analysis of PAX6 in liver tissues. Gene methylation was determined in 29 normal controls (NC) and 160 paired hepatocellular carcinoma (HCC) tissues and their adjacent non-tumor tissues (NT) by Q-MSP. The results are represented as the difference in the methylation index. The black lines indicate the mean of the methylation index. The p value for the methylation levels among the groups was computed from Wilcoxon rank-sum test (NC vs HCC and NC vs NT) and Wilcoxon signed-rank test (NT vs HCC) (a). The best cutoff value for the methylation index (MI) and the area under the receiver operating characteristic curve (AUC) were calculated to discriminate 29 normal controls and 160 HCC (b). Gene methylation was respectively determined in normal controls (NC) and paired hepatocellular carcinoma (HCC) tissues and their adjacent non-tumor tissues (NT) by etiologic factors. The p value for methylation levels among the groups was computed from Wilcoxon rank-sum test (NC vs HCC and NC vs NT) and Wilcoxon signed-rank test (NT vs HCC) (c)

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