Fig. 5

Western blot analysis of apoptotic markers in Myc-induced cells in the presence of wild-type or mutated JMJD6. NMuMG cells were treated with 150 nM 4-OHT to induce Myc or ethanol and placed in glucose- or glutamine-free media or treated with 100 mM of etoposide. Expression of cleaved PARP and cleaved caspase 3 was determined by Western blot demonstrating reduced levels in the presence of wild-type, but not mutant, JMJD6