Skip to main content
Fig. 4 | Clinical Epigenetics

Fig. 4

From: The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis

Fig. 4

Overexpression of wild-type, but not mutated, JMJD6 suppresses Myc-induced cell death in response to different stress conditions. NMuMG cells stably expressing MycERTM or empty pBabe vector were transduced with JMJD6-V5 or LacZ-V5 control. Cells were treated with 4-OHT or ethanol as in Fig. 3 and placed in glucose-free (a), serum-free (b), or glutamine-free (c) media or treated with etoposide (d) for another 20 h. Cell death was measured as in Fig. 3. Black bars—MycOFF, open bars—MycON. e Catalytically inactive JMJD6H187A (JMJD6mut) is not able to suppress Myc-induced cell death. *p < 0.05, **p < 0.01. f Western blot analysis shows equal ectopic expression of JMJD6 or mutated JMJD6 in NMuMG cells with our without Myc expression

Back to article page