Skip to main content

Table 3 Associations between MGMT promoter methylation status, demographic features, and grade of 65 IDH1 wt glioma patients and PFS and OS, assessed by univariate (log-rank test) and multivariate (Cox-regression) analyses

From: MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response

 

PFS

OS

Univariate (p)

Multivariate (HR, 95% CI, p)

Univariate (p)

Multivariate (HR, 95% CI, p)

MSP me

0.718

1.456, 0.730–2.903, 0.285

0.345

1.270, 0.606–2.661, 0.527

PSQ me

0.030

0.729, 0.358–1.482, 0.382

0.031

0.762, 0.376–1.544, 0.450

HRM me

0.013

0.539, 0.278–1.045, 0.067

0.006

0.473, 0.231–0.969, 0.041

Sex = woman

0.742

0.958, 0.545–1.684, 0.881

0.578

0.918, 0.494–1.705, 0.786

Age <70

0.106

0.677, 0.389–1.178, 0.168

0.114

0.590, 0.331–1.052, 0.074