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Table 3 Associations between MGMT promoter methylation status, demographic features, and grade of 65 IDH1 wt glioma patients and PFS and OS, assessed by univariate (log-rank test) and multivariate (Cox-regression) analyses

From: MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response

  PFS OS
Univariate (p) Multivariate (HR, 95% CI, p) Univariate (p) Multivariate (HR, 95% CI, p)
MSP me 0.718 1.456, 0.730–2.903, 0.285 0.345 1.270, 0.606–2.661, 0.527
PSQ me 0.030 0.729, 0.358–1.482, 0.382 0.031 0.762, 0.376–1.544, 0.450
HRM me 0.013 0.539, 0.278–1.045, 0.067 0.006 0.473, 0.231–0.969, 0.041
Sex = woman 0.742 0.958, 0.545–1.684, 0.881 0.578 0.918, 0.494–1.705, 0.786
Age <70 0.106 0.677, 0.389–1.178, 0.168 0.114 0.590, 0.331–1.052, 0.074
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