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Fig. 1 | Clinical Epigenetics

Fig. 1

From: MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response

Fig. 1

HRM analysis in glioma cell lines. a MGMT promoter methylation was analyzed by HRM, MSP, and PSQ. The regions in the MGMT promoter analyzed by each of the assays are shown. b MGMT promoter methylation of 14 GBM cell lines measured by HRM (in triplicates) and the corresponding MSP categorization (m methylated; u unmethylated). Ordinate shows the methylation level determined by HRM. c Relationship between MGMT suicide-enzyme activity and level of promoter methylation determined by HRM using the r4 primer in 14 GBM cell lines. A correlation between MGMT promoter methylation and MGMT activity was found (r = −0.69; p < 0.01)

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